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Which of the following has the least GI effect and derived from parent NSAIDs?

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Which of the following has the least GI effect and derived from parent NSAIDs?

(a) Piroxicam

(b) Phenylbutazone

(c) NO-NSAIDs

(d) Indomethacin

The question was asked in an interview for job.

The doubt is from Drug Addiction and Abuse topic in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

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The correct answer is (c) NO-NSAIDs

To elaborate: Nitric oxide-releasing NSAIDs. It has fewer GI effects than parent NSAID from which they are derived. It has a comparable anti-inflammatory effect and superior analgesic effect. The parent NSAID is Naproxen. The possible mechanism can be that nitric oxide improves gastric blood flow.

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