Question

Which of the following is a non-competitive inhibitor against protease produced by HIV?

(a) Tipranavir

(b) Acetylcholinesterase

(c) Ritonavir

(d) Phenicols

I had been asked this question by my college professor while I was bunking the class.

My question is based upon Enzymes as Biological Catalysts in division Bioenergetics, Enzymes, Metabolism, Genes, Chromosomes and Genomes of Cell Biology

Answer 1

The correct answer is (a) Tipranavir

To elaborate: In noncompetitive inhibition, the substrate and inhibitor do not compete for the active site of the enzyme and the inhibitor generally act at other site to bind to the enzyme. The level of inhibition depends on concentration of the inhibitor. Tipranavir is non-competitive inhibitor of the protease produced by HIV when HIV infects a white blood cell. Ritonavir is a competitive inhibitor of the protease and resembles the its peptide substate.