Question

Neurofibrillary tangles, found in the brain cells of persons with neurodegenerative disorders consists of _______________

(a) intermediate filaments

(b) microtubule-associated proteins

(c) microtubules

(d) phospholipids

I had been asked this question during an internship interview.

Question is taken from Cytoskeleton topic in division Cytoskeleton and Cell Motility of Cell Biology

Answer 1

Correct choice is (b) microtubule-associated proteins

For explanation I would say: Neurofibrillary tangles found in the brain cells of neurodegenerative diseases’ patients consists of tangled filaments of excessively phosphorylated ‘tau’ molecules. Tau molecules are a type of MAPs (microtubule-associated proteins).