Question

During the formation of the peptide bond which of the following takes place?

(a) Hydroxyl group is lost from its carboxyl group of one amino acid and a hydrogen atom is lost from its amino group of another amino acid

(b) Hydrogen atom is lost from its carboxyl group of one amino acid and a hydroxyl group is lost from its amino group of another amino acid

(c) Hydroxyl group is lost from its carboxyl group of one amino acid and a hydroxyl group is lost from its amino group of another amino acid

(d) Hydrogen atom is lost from its carboxyl group of one amino acid and a hydrogen atom is lost from its amino group of another amino acid

The question was posed to me in an online quiz.

The doubt is from Peptides and Proteins topic in section Amino Acids, Peptides and Proteins of Biochemistry

Answer 1

The correct choice is (a) Hydroxyl group is lost from its carboxyl group of one amino acid and a hydrogen atom is lost from its amino group of another amino acid

Explanation: The α-amino group of one amino acid acts as a nucleophile to displace the hydroxyl group of another amino acid forming a peptide bond.