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Native state of a protein can be disrupted by __________

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Native state of a protein can be disrupted by __________

(a) Temperature

(b) pH

(c) Removal of water

(d) Presence of hydrophilic surfaces

I got this question in an interview for internship.

The query is from The Covalent Structure of Proteins in chapter Amino Acids, Peptides and Proteins of Biochemistry

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The correct answer is (d) Presence of hydrophilic surfaces

The best I can explain: Native state of a protein can be disrupted by temperature, pH, Removal of water and presence of hydrophobic surfaces.

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