Question

By whom and when were the Bayesian methods applied first?

(a) Smith-Waterman, 1981

(b) Agarwal and States, 1996

(c) Smith-Waterman, 1996

(d) Agarwal and States, 1981

This question was posed to me in final exam.

This interesting question is from Bayesian Statistics topic in portion Sequence Alignment of Bioinformatics

Answer 1

Right choice is (b) Agarwal and States, 1996

The best I can explain: Agarwal and States, in1996, have applied Bayesian methods to provide the best estimate of the evolutionary distance between two DNA sequences. For example, sequences of the same length that have a certain level of mismatches.