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When random or unrelated sequences are compared using a global alignment method, they can have ____________ reflecting the tendency of the global algorithm to match as many characters as possible.

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When random or unrelated sequences are compared using a global alignment method, they can have ____________ reflecting the tendency of the global algorithm to match as many characters as possible.

(a) very low scores

(b) very high scores

(c) moderate scores

(d) low scores

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The origin of the question is Assessing the Significance of Sequence Alignments topic in portion Sequence Alignment of Bioinformatics

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The correct choice is (b) very high scores

Easiest explanation: The significance of the scores of global alignments, is more difficult to determine. Using the Needleman-Wunsch algorithm and a suitable scoring system, there are many ways to produce a global alignment between any pair of sequences, and the scores of many different alignments may be quite similar hence the scores obtained might be unusually high.

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