Question

In FASTA, neighboring high-scoring segments along the same diagonal are selected and joined to form a single alignment.

(a) True

(b) False

I had been asked this question in unit test.

This is a very interesting question from FASTA in portion Database Similarity Searching of Bioinformatics

Answer 1

The correct option is (a) True

The explanation is: This step allows introducing gaps between the diagonals while applying gap penalties. The score of the gapped alignment is calculated again. In step 3, the gapped alignment is refined further using the Smith–Waterman algorithm to produce a final alignment.