Question

Which of the following is true about phosphodiester linkage?

(a) 5’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide

(b) 3’-phosphate group of one nucleotide unit is joined to the 5’-hydroxyl group of the next nucleotide

(c) 5’-phosphate group of one nucleotide unit is joined to the 5’-hydroxyl group of the next nucleotide

(d) 3’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide

I got this question in examination.

The question is from Nucleotides & Nucleic Acids Basics topic in chapter Nucleotides and Nucleic Acids of Biochemistry

Answer 1

Right option is (a) 5’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide

For explanation: 5’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide.