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Which of the following serves as a specific binding site for the proteins involved in membrane fusion during exocytosis?

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Which of the following serves as a specific binding site for the proteins involved in membrane fusion during exocytosis?

(a) Phosphatidylinositol

(b) Phosphatidylinositol 4, 5-biphosphate

(c) Phosphatidylinositol 3, 5-biphosphate

(d) Phosphatidylinositol 3, 4-biphosphate

I have been asked this question in an interview for internship.

My question is based upon Lipids as Signals, Cofactors, and Pigments in chapter Lipids, Biological Membranes and Transport of Biochemistry

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Best answer
The correct option is (b) Phosphatidylinositol 4, 5-biphosphate

Best explanation: Phosphatidylinositol 4, 5-biphosphate in the cytoplasmic face of plasma membranes serves as a specific binding site for certain cytoskeletal proteins and for some soluble proteins involved in membranes fusion during exocytosis.

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