Question

Which of the following is untrue about Protein substitution matrices?

(a) They are significantly more complex than DNA scoring matrices

(b) They have the N x N matrices of the amino acids

(c) Protein substitution matrices have quite important role in evolutionary studies

(d) They are significantly quite less complex than DNA scoring matrices

The question was posed to me in exam.

I want to ask this question from Needleman in chapter Multiple Sequence Alignment of Bioinformatics

Answer 1

The correct answer is (d) They are significantly quite less complex than DNA scoring matrices

For explanation I would say: Protein substitution matrices are significantly more complex than DNA scoring matrices. Proteins are composed of twenty amino acids, and physico-chemical properties of individual amino acids vary considerably. A protein substitution matrix can be based on any property of amino acids: size, polarity, charge, hydrophobicity.