Question

Whenever the cell’s ATP supply is depleted, which of the following enzyme’s activity is increased?

(a) Hexokinase

(b) Pyruvate kinase

(c) Glucokinase

(d) Phosphofructokinase-1

I have been asked this question during a job interview.

I'd like to ask this question from Glycolysis topic in section Principles of Bioenergetics and Glycolysis of Biochemistry

Answer 1

The correct choice is (d) Phosphofructokinase-1

The best I can explain: Phosphofructokinase-1 is a regulatory enzyme; it is the major point of regulation in glycolysis. Its activity is increased whenever the cell’s ATP supply is depleted.