Question

The mutation which cannot give rise to an oncogene?

(a) Addition or deletion of a base producing a nonsense message and an inactive protein product

(b) A point mutation changing just one amino acid in protein product

(c) A translocation, putting gene under control of strong promoter producing over expression

(d) A point mutation producing stop codon, premature termination

This question was posed to me in final exam.

This key question is from Oncogenes, Tumor Suppressor Genes and Programmed Cell Death topic in section Biosignalling of Biochemistry

Answer 1

Right answer is (a) Addition or deletion of a base producing a nonsense message and an inactive protein product

Explanation: Addition or deletion of a base producing a nonsense message and an inactive protein product cannot produce an oncogene.