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Which of the following are the structural motifs that mediate protein-protein interactions?

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Which of the following are the structural motifs that mediate protein-protein interactions?

(a) Leucine zipper and basic helix-loop-helix

(b) Homeodomain

(c) Zinc finger

(d) Helix-turn-helix

The question was asked in a job interview.

Question is from Principles of Gene Regulation in section Regulation of Gene Expression and Miscellaneous of Biochemistry

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The correct choice is (a) Leucine zipper and basic helix-loop-helix

The explanation: Regulatory proteins contain domains not only for DNA binding but also for protein-protein interactions. Homeodomain, zinc finger and helix-turn-helix are DNA-binding domains.

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