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Over-twisting of a molecule results in ____________

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Over-twisting of a molecule results in ____________

(a) Negative supercoiling

(b) Positive supercoiling

(c) Elongation

(d) Compression

I have been asked this question in semester exam.

This is a very interesting question from DNA Supercoiling topic in section Genes and Chromosomes of Biochemistry

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The correct choice is (b) Positive supercoiling

Explanation: Extra helical twisting leads to positive supercoiling, while subtractive twisting leads to negative supercoiling.

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