Question

The scans for lissencephaly will show a brain _______

(a) with no gyri and sulci

(b) with excess gyri and sulci

(c) with deformed brain structure

(d) with a smaller than normal brain size

I had been asked this question in an international level competition.

Enquiry is from MRI topic in division Diagnostic Investigation via Imaging Techniques of Clinical Science

Answer 1

Correct option is (a) with no gyri and sulci

The explanation is: Lissencephaly is a neuronal defect that is present right from birth. It may or may not be detected in the fetal stage. In this disorder, the brain in smooth without the presence of any gyri and sulci. A child born with lissencephaly often has a normal head structure so it is often difficult to detect the presence of this defect till a later age.