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Glucagon and epinephrine stimulate glycogen breakdown to glucose 6-phosphate ________

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Glucagon and epinephrine stimulate glycogen breakdown to glucose 6-phosphate ________

(a) Directly by binding to glycogen phosphorylase

(b) Indirectly by first stimulating adenylate cyclase to make cAMP

(c) Only in the liver

(d) Only in muscle cells

I got this question in an interview for internship.

I'm obligated to ask this question of Coordinated Regulation of Glycogen Synthesis and Breakdown in division Principles of Metabolic Regulation: Glucose and Glycogen of Biochemistry

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The correct choice is (b) Indirectly by first stimulating adenylate cyclase to make cAMP

The explanation: The second messenger cAMP increases in concentration in response to stimulation by epinephrine in muscle or glucagon in liver.

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