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Which of the following does not affect the stability of an α-helix?

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Which of the following does not affect the stability of an α-helix?

(a) Electrostatic repulsion

(b) Bulkiness

(c) Interaction between R groups spaced three residues apart

(d) Occurrence of alanine and glycine residues

The question was asked during a job interview.

This key question is from Tricky Questions and Answers in chapter Regulation of Gene Expression and Miscellaneous of Biochemistry

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Best answer
Right choice is (d) Occurrence of alanine and glycine residues

Best explanation: The occurrence of Proline and Glycine residues affects the stability of an α-helix.

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