Question

Which of the following is untrue regarding Chou–Fasman and GOR methods?

(a) Both are the first-generation methods

(b) They are developed in the 1970s,

(c) They suffer from the fact that the prediction rules are somewhat arbitrary

(d) They are based on single sequence statistics with clear relation to known protein-folding theories

The question was asked in an interview for internship.

The above asked question is from Protein Secondary Structure Prediction  for Globular Proteins in chapter Secondary Structure Prediction of Bioinformatics

Answer 1

Correct choice is (d) They are based on single sequence statistics with clear relation to known protein-folding theories

For explanation I would say: They are based on single sequence statistics without clear relation to known protein-folding theories. The predictions solely rely on local sequence information and fail to take into account long range interactions. A Chou-Fasman–based prediction does not even consider the short-range environmental information.