Question

The main disadvantage of maximum likelihood methods is that they are _____

(a) mathematically less folded

(b) mathematically less complex

(c) computationally lucid

(d) computationally intense

This question was addressed to me in examination.

This intriguing question originated from The Maximum Likelihood Approach in chapter Phylogenetic Tree Construction Methods and Programs of Bioinformatics

Answer 1

Correct answer is (d) computationally intense

For explanation: The main disadvantage of maximum likelihood methods is that they are computationally intense. However, with faster computers, the maximum likelihood method is seeing wider use and is being used for more complex models of evolution.