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Which of the following is untrue regarding the programs for analysis of nucleic acid sequences?

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Which of the following is untrue regarding the programs for analysis of nucleic acid sequences?

(a) DNAPARS treats gaps as a fifth nucleotide state

(b) DNAPENNY performs parsimonious phylogenies by branch-and-bound search

(c) DNAPENNY can analyze sequences up to 11 or 12

(d) Compatibility criterion is not involved in DNACOMP

The question was posed to me during an interview for a job.

This key question is from Maximum Parsimony Method topic in division Phylogenetic Tree Construction Methods and Programs of Bioinformatics

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The correct option is (d) Compatibility criterion is not involved in DNACOMP

Explanation: DNACOMP performs phylogenetic analysis using the compatibility criterion.

Rather than searching for overall parsimony at all sites in the multiple sequence alignment, this method finds the tree that supports the largest number of sites. This method is recommended when the rate of evolution varies among sites.

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