Question

Which of the given statements is incorrect about Microarray Analysis?

(a) It is designed to detect global changes in transcription in a genome

(b) It provides information about the levels of protein products of the genes

(c) The proteins are first separated in a column on the basis of size and then across a second dimension on a slab on the basis of charge

(d) Labeled protein samples may also be extracted from treated cells and separated by two-dimensional gel electrophoresis

This question was addressed to me by my college professor while I was bunking the class.

The origin of the question is Global Gene Regulation in division Genome Analysis of Bioinformatics

Answer 1

Right option is (b) It provides information about the levels of protein products of the genes

Easy explanation: Microarray analysis is designed to detect global changes in transcription in a genome but does not provide information about the levels of protein products of the genes, which may also be subject to translational regulation. This method also can resolve thousands of proteins based on size and charge. There are databases of the patterns found in different organisms.