Question

While sequencing of the first bacterial genome–A large number of random overlapping fragments were sequenced and then a consensus sequence of the entire ______ chromosome of Hemophilus was assembled by computer.

(a) 8.6 x 10^9 bp

(b) 1.8 x 10^6 bp

(c) 6.9 x 10^5 bp

(d) 1.8 x 10^4 bp

The question was posed to me by my school teacher while I was bunking the class.

The origin of the question is Genome Anatomy in section Collecting & Storing Sequences in Laboratory of Bioinformatics

Answer 1

Right option is (b) 1.8 x 10^6 bp

Explanation: It was done excepting several regions that had to be assembled manually. Once available, open reading frames were identified, and these were compared to the existing proteins by a database similarity search.