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Baculovirus infects insect cell lines and are also pathogenic to humans. (a)True

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Baculovirus infects insect cell lines and are also pathogenic to humans.

(a) True

(b) False

The question was posed to me by my college professor while I was bunking the class.

This is a very interesting question from Guidelines for Choosing Host-Vector Systems in portion Utilizing Genetically Engineered Organisms & Medical Applications of Bioprocess Engineering of Bioprocess Engineering

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The correct answer is (b) False

The explanation is: The baculovirus that infects insect cells is an ideal vector for genetic engineering, because it is nonpathogenic to humans and has a very strong promoter that encodes for a protein that is not essential for virus production in cell culture. The insertion of a gene under the control of this promoter can lead to high expression levels (40% of the total protein as the target protein).

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