Question

Antibody fragments are advantageous than Monoclonal antibodies.

(a) True

(b) False

The question was posed to me during an online exam.

Question is taken from Products of Animal Cell Cultures in chapter Bioprocess Considerations in Using Animal Cell Cultures of Bioprocess Engineering

Answer 1

The correct option is (a) True

To elaborate: The large size of MAb’s has limited their ability to penetrate some tumors. Antibody fragments can be used instead; these products can be made in nonmammalian cells. The use of smaller fragments enables deeper penetration with the affinity of the antibody also being critical and if it is too high this will restrict its ability to penetrate a tumour.