Question

Serum does not require sterilization.

(a) True

(b) False

This question was addressed to me in an interview.

My question is based upon Methods Used for the Cultivation of Animal Cells topic in chapter Bioprocess Considerations in Using Animal Cell Cultures of Bioprocess Engineering

Answer 1

Right option is (b) False

Best explanation: Serum must be filtered sterilized, and contamination with viruses and possibly mycoplasma (a wall less bacterium) are potential problems. Contamination by prions (agents that cause diseases such as “mad cow” disease) is a real concern, and source animals cannot come from regions known to have contaminated animals.