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Unequal crossing over takes place due to _______________ of chromosomes.

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Unequal crossing over takes place due to _______________ of chromosomes.

(a) denaturation

(b) misalignment

(c) aggregation

(d) condensation

This question was addressed to me in an interview for job.

My question is based upon Genome Stability topic in chapter Nature of Genome of Cell Biology

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Right option is (b) misalignment

For explanation I would say: Unequal crossing over takes place due to misalignment of chromosomes during meiosis. As a result one chromosome receives and extra segment of DNA (duplication) and the other chromosome loses a segment of DNA (deletion).

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