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The Wiskott-Aldrich syndrome is caused due the lack of functional ____________ protein.

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The Wiskott-Aldrich syndrome is caused due the lack of functional ____________ protein.

(a) ActA

(b) Arf1

(c) WASP

(d) WAVE

This question was posed to me in an interview for job.

This is a very interesting question from Non-muscle Motility in chapter Cytoskeleton and Cell Motility of Cell Biology

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Correct option is (c) WASP

To explain I would say: Mammalian cells have a family of proteins (WASP/WAVE family) that activates Arp 2/3 complex at the site of stimulation near the plasma membrane. Patients of Wiscott-Aldris syndrome lack the functional WASP protein in their white blood cells.

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