Question

A rare disease congenital agammaglobulinemia is caused due to abnormality in __________________

(a) humoral antibody

(b) cell-mediated immunity

(c) acidic/alkaline pH

(d) homeostasis

The question was asked during a job interview.

My question is taken from The Immune Response in section Immune Response of Cell Biology

Answer 1

The correct answer is:

(a) humoral antibody

Explanation:

Congenital agammaglobulinemia is a rare genetic disorder in which the body is unable to produce antibodies, particularly immunoglobulins, due to a defect in B lymphocytes. B cells are responsible for the production of antibodies, which are a key part of the humoral immune response. In individuals with agammaglobulinemia, B cells fail to mature properly, leading to a lack of antibodies (immunoglobulins), which makes the individual highly susceptible to infections.

Correct Answer: (a) humoral antibody