Question

Which protein mentioned below can reverse central dogma?

(a) Ribosome

(b) Restriction Endonuclease

(c) Reverse Transcriptase

(d) RNA Polymerase

This question was posed to me during an interview.

The question is from Transcription in Prokaryotes : Initiation topic in division Gene Expression : Transcription Prokaryotes of Cytogenetics

Answer 1

Correct answer is (c) Reverse Transcriptase

The explanation is: Reverse transcriptase helps in cDNA synthesis from RNA, which is opposite to the central dogma, where RNA is synthesized from DNA. Ribosome and RNA polymerases obey central dogma, while Restriction Endonuclease is unrelated as it simply cleaves DNA at a specific site.