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Colchicine is used to cause______________

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Colchicine is used to cause______________

(a) Mitotic non-disjunction

(b) Meiotic non-disjunction

(c) Mitotic disjunction

(d) Meiotic disjunction

I had been asked this question in an internship interview.

The above asked question is from Chromosomal Abnormalities : Euploidy in section Chromosomal Basis of Inheritance of Cytogenetics

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The correct choice is (a) Mitotic non-disjunction

Easiest explanation: Colchinine causes an arrest in anaphase which leads to mitotic non-disjunction halting the mitosis. This leads to doubling of chromosome as the duplicated chromatins fail to separate.

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