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Neurofibrilomatosis varies in ________________

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Neurofibrilomatosis varies in ________________

(a) Penetrance

(b) Expressivity

(c) Both penetrance and expressivity

(d) It is 100% penetrant and expressive

The question was posed to me at a job interview.

Question is taken from Penetrance and Expressivity topic in chapter Regulating Gene Expression in Eukaryotes of Cytogenetics

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Correct option is (c) Both penetrance and expressivity

To explain: Neurofibrilomatosis is an autosomal dominant trait that causes tumour lie growth all over the body. It is 50-80% penetrant and varies in expressivity.

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