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X linked dominant trait tends to be milder in heterozygous females. State if it is true or false.

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X linked dominant trait tends to be milder in heterozygous females. State if it is true or false.

(a) True

(b) False

The question was asked at a job interview.

My query is from Sex Linked Inheritance topic in portion Chromosomes and Sex Determination of Cytogenetics

1 Answer

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The correct answer is (a) True

Explanation: As females have two copies of X gene, if only one of them is mutant there is a 50% chance of the mutant X gene being turned off in a cell due to dosage compensation. Thus, the effect of the mutant gene product is diluted.

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