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Klinefelter syndrome results due to ____________

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Klinefelter syndrome results due to ____________

(a) Non-disjunction in the male gamete

(b) Non-disjunction in the female gamete

(c) Gradual loss of chromosome

(d) Non-disjunction in any of the gametes

I have been asked this question in an interview.

My question comes from Sex Determination in Mammals in section Chromosomes and Sex Determination of Cytogenetics

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The correct answer is (d) Non-disjunction in any of the gametes

To explain: Klinefelter syndrome results from a genetic combination AA+ XXY; this can result from non-disjunction in either male or female gamete.

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