Question

Due to the translocation process, the XIC from one X chromosome in a woman passed to chromosome 3. The individual died. What were the probable reasons of death?

(a) The X chromosome was unable to show its effect

(b) Both X chromosome being active too much gene product was produced

(c) Inactivation of chromosome 3

(d) Hyper activation of autosomes

The question was posed to me in my homework.

This is a very interesting question from Dosage Compensation Mechanism for X linked Genes in chapter Chromosomes and Sex Determination of Cytogenetics

Answer 1

Correct answer is (c) Inactivation of chromosome 3

The explanation: As XIC translocated to chromosome 3 now it can be counted as an X chromosome. In some cells randomly this chromosome 3 is condensed and inactivated which prevents the important autosomal gene product from being formed. Thus the individual dies.