Question

Administration of general anesthetics decreases the presynaptic Ca^2+ entry.

(a) True

(b) False

The question was posed to me in examination.

My question is based upon Mechanism of Action of General Anesthetics topic in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

Answer 1

Right choice is (a) True

For explanation I would say: Administration of general anesthetics decreases the presynaptic Ca^2+ entry, thus decreases the neurotransmitter release. It increases postsynaptic Cl^– entry and also increases postsynaptic K^+ leakage from the cell. Local anesthetics help block conduction. It decreases the axonal Na+ entry thus prevents action potential propagation.