Question

__________ demonstrated a plasmid-induced immune response using mice by inoculating with a plasmid expressing human growth hormone which elicited antibodies instead of faltering growth.

(a) Stephen Johnston

(b) Karry Mullis

(c) Robert Hook

(d) Alexander Fleming

The question was posed to me during an interview.

I would like to ask this question from Immunological Preparations topic in division Immunological Preparations of Drug Biotechnology

Answer 1

Right answer is (a) Stephen Johnston

Best explanation: Stephen Johnston’s group saw that when mice are inoculated with plasmid DNA encoding human growth hormone, the mice is able to produce antibodies against this hormone. It was the first demonstration of a plasmid-induced immune response was when mice inoculated with a plasmid expressing human growth hormone elicited antibodies instead of faltering growth.