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During purine synthesis the activity of amidotransferase enzyme is inhibited by the antitumor agent, mark the correct one.

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During purine synthesis the activity of amidotransferase enzyme is inhibited by the antitumor agent, mark the correct one.

(a) Aminopterin

(b) Methotrexate

(c) Texol

(d) Azaserine

I had been asked this question by my college professor while I was bunking the class.

Enquiry is from Nucleotide Metabolism topic in division Bioenergetics and Metabolism of Life Sciences

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The correct answer is (d) Azaserine

The best explanation: Azaserine is the structural analog of glutamine and works as an antitumor agent by preventing the activity of enzyme amidotransferase which in turn block purine synthesis.

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