Question

Which of the following steps is NOT involved in the activation of T-cell?

(a) Double positive cell converts to single positive T-cell

(b) Foreign peptide bound to MHC provide signals

(c) CD28 of TCR interacts with B7 of APC

(d) CD23 has ITAM, which transducer signals

I had been asked this question during an interview for a job.

Origin of the question is T-Cells topic in chapter Immunology of Life Sciences

Answer 1

Right option is (a) Double positive cell converts to single positive T-cell

Explanation: The conversion of double positive cells to a single positive cell is thymic selection process in which T-cell mature with the interaction of MHC and develops the tolerance to self-antigen.