Question

If the bond between the enzyme and inhibiting drug is very strong, which of the following takes place?

(a) The active site slowly regains its original shape

(b) The enzyme develops a new active site

(c) The enzyme is blocked temporarily

(d) The body synthesizes a new enzyme

This question was posed to me during a job interview.

This intriguing question originated from Drug-Target Interaction in chapter Chemistry in Everyday Life of Chemistry – Class 12

Answer 1

Correct choice is (d) The body synthesizes a new enzyme

Easy explanation: When there is a strong covalent bond between the enzyme and the drug, the enzyme is blocked permanently. This results in the degradation of the entire drug-enzyme complex and the synthesis of a new enzyme.