Question

Which of the chromosome mutation leads to Beta-thalassemia?

(a) 21

(b) 10

(c) 11

(d) 13

I got this question in an online quiz.

Query is from Inheritance and Variation Principles in division Principles of Inheritance and Variation of Biology – Class 12

Answer 1

Right answer is (c) 11

To elaborate: The mutation in the HBB gene on chromosome number 11 leads to the disorder beta-thalassemia. It is inherited as an autosomal recessive trait. The severity of beta-thalassemia depends upon the nature of the mutation.