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ADA deficiency is caused due to ________ of the gene for adenosine deaminase.

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in Biology – Class 12 by (271k points)
ADA deficiency is caused due to ________ of the gene for adenosine deaminase.

(a) addition

(b) change

(c) deletion

(d) multiplication

This question was addressed to me during an interview.

The above asked question is from Biotechnological Applications in Medicine: Gene Therapy topic in chapter Biotechnology and its Applications of Biology – Class 12

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Right answer is (c) deletion

The explanation is: ADA deficiency is caused due to the deletion of the gene responsible for synthesizing the enzyme adenosine deaminase. This enzyme is involved in purine metabolism and its deficiency leads to immune disorder.

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