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The assumption in this evolutionary model is that the amino acid substitutions observed over short periods of evolutionary history can be extrapolated to longer distances.

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The assumption in this evolutionary model is that the amino acid substitutions observed over short periods of evolutionary history can be extrapolated to longer distances.

(a) True

(b) False

This question was addressed to me by my college director while I was bunking the class.

Origin of the question is Use of Scoring Matrices and Gap Penalties in Sequence Alignments in portion Sequence Alignment of Bioinformatics

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The correct choice is (a) True

To elaborate: The BLOSUM matrices are based on scoring substitutions found over a range of evolutionary periods and reveal that substitutions are not always as predicted by the PAM model. The purpose of assumption in this evolutionary model is to make predictions.

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