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Dayhoff PAM matrices, are based on an evolutionary model of protein change, whereas, BLOSUM matrices, are designed to identify members of the same family.

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Dayhoff PAM matrices, are based on an evolutionary model of protein change, whereas, BLOSUM matrices, are designed to identify members of the same family.

(a) True

(b) False

I had been asked this question during an online exam.

My question is from Dynamic Programming Algorithm for Sequence Alignment topic in chapter Sequence Alignment of Bioinformatics

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Correct choice is (a) True

The explanation is: There is a very large number amino acid scoring matrices in use, some much more popular than others, and these scoring matrices are designed for different purposes. Some, such as the Dayhoff PAM matrices, are based on an evolutionary model of protein change, whereas others, such as the BLOSUM matrices, are designed to identify members of the same family. Alignments between DNA sequences require similar kinds of considerations.

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