Question

Which state of the ‘Rabs’ is the active state?

(a) GDP-bound

(b) GTP-bound

(c) Membrane-bound

(d) Lipid-bound

I had been asked this question during an interview for a job.

The above asked question is from Cytoplasmic Membrane Systems topic in section Cytoplasmic Membrane Systems of Cell Biology

Answer 1

Right answer is (b) GTP-bound

Best explanation: The ‘Rabs’ are encoded by over 60 diverse genes in humans and they cycle between two states; GTP-bound active state and GDP-bound inactive state.