Question

Protein A will fold into its native state only when protein B is also present in the solution. However, protein B can fold itself into native confirmation without the presence of protein A. Which of the following is true?

(a) Protein B serves as precursor for protein A

(b) Protein B serves as molecular chaperon for protein A

(c) Protein B serves as ligand for protein A

(d) Protein B serves as structural motif for protein A

This question was addressed to me during an online interview.

This key question is from Protein Denaturation and Folding in section Three Dimensional Structure Of Proteins and Protein Function of Biochemistry

Answer 1

Correct answer is (b) Protein B serves as molecular chaperon for protein A

The explanation is: Not all proteins fold spontaneously as they are synthesized in the cell. Folding for many proteins is facilitated by the action of specialized proteins known as molecular chaperons.