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Conserved positions have _____ residues and bigger symbols.

(a) fewer

(b) more

(c) maximum

(d) minimum

The question was posed to me in a job interview.

Query is from Motif Discovery in Unaligned Sequences in portion Sequence Alignment of Bioinformatics

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Right option is (a) fewer

The explanation: The options maximum and minimum are comparatively obsolete as there involves the studies of alignment. Conserved positions have fewer residues and bigger symbols; whereas less conserved positions have a more heterogeneous mixture of smaller symbols stacked together. In general, a sequence logo provides a clearer description of a consensus sequence.

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