Question

The degree of sequence variation in the alignment reveals evolutionary relatedness of different sequences, whereas the conservation between sequences reflects the changes that have occurred during evolution in the form of substitutions, insertions, and deletions.

(a) True

(b) False

I had been asked this question in an interview for internship.

Question is from Sequence Homology Versus Sequence Similarity and Identity in section Pairwise Sequence Alignment of Bioinformatics

Answer 1

The correct answer is (b) False

The best explanation: The degree of sequence conservation in the alignment reveals evolutionary relatedness of different sequences, whereas the variation between sequences reflects the changes that have occurred during evolution in the form of substitutions, insertions, and deletions. Identifying the evolutionary relationships between sequences helps to characterize the function of unknown sequences. When a sequence alignment reveals significant similarity among a group of sequences, they can be considered as belonging to the same family.