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The substitution matrices are rarely used in this type of matching.

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The substitution matrices are rarely used in this type of matching.

(a) True

(b) False

I have been asked this question during an online interview.

Enquiry is from Needleman topic in portion Multiple Sequence Alignment of Bioinformatics

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Correct answer is (b) False

For explanation: The substitution matrices are quite commonly used in this type of matching. A concise way to express the residue substitution costs can be achieved with a N x N matrix where, N is 4 for DNA and 20 for proteins as 4 nucleotides in DNA and 20 amino acid residues in proteins are in picture respectively.

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