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In the initial step of EM algorithm, the 20-residue-long binding motif patterns in each sequence are aligned as an initial guess of the motif.

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In the initial step of EM algorithm, the 20-residue-long binding motif patterns in each sequence are aligned as an initial guess of the motif.

(a) True

(b) False

The question was asked by my college director while I was bunking the class.

I want to ask this question from Statistical Methods for Aiding Alignment in chapter Multiple Sequence Alignment of Bioinformatics

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Right option is (a) True

The explanation: The base composition of each column in the aligned patterns is then determined. The composition of the flanking sequence on each side of the site provides the surrounding base or amino acid composition for comparison. Each sequence is assumed to be the same length and to be aligned by the ends.

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